What is contained within the nucleosomal core?

The nucleosomal core is primarily composed of proteins known as histones. These histones play a crucial role in organizing and compacting DNA within the nucleus of eukaryotic cells. Each nucleosome consists of a segment of DNA wrapped around a core of eight histone proteins, specifically two copies of each of the four core histones (H2A, H2B, H3, and H4). This structure allows for the efficient packaging of DNA, facilitating both its protection and regulation during processes such as replication and transcription.

The arrangement of DNA around histones forms a fundamental unit of chromatin, which is key for gene expression and cellular function. The interaction between DNA and histones is also important for the dynamic regulation of chromatin structure, influencing accessibility for various cellular processes.