True or False: A single-pass trans-membrane protein that is an alpha helix can create a channel.

A single-pass trans-membrane protein typically spans the membrane only once and is structured in a way that it cannot form a channel. This is due to the fact that a channel requires the protein to have multiple regions that span the membrane to create an opening through which ions or molecules can pass. An alpha helix configuration, while common in trans-membrane proteins, does not provide the structural complexity needed to form a channel on its own in a single-pass orientation.

Channels are typically formed by multi-pass trans-membrane proteins, which allow for the formation of a continuous hydrophilic path through the membrane. These proteins can have multiple alpha helices that align to create a pore. Conversely, peripheral proteins, which are not embedded in the membrane, are also unable to create channels since they do not span the membrane at all. Thus, the statement that a single-pass trans-membrane protein that is an alpha helix can create a channel is false.